Quancard, Jean, bach, anders, cox, brian, craft, russel, finsinger, dirk, gueret , stephanie, hartung, ingo, laufer, stefan, messinger, josef, sbardella, gianluca and koolman, hannes (2021) The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery. ChemMedChem : chemistry enabling drug discovery.

Abstract

Phenotypic Drug Discovery has a long track record of delivering innovative drugs and has received renewed attention in the last few years. The promise of this approach, however, comes with several challenges which should be addressed to avoid wasting time and resources on drugs with undesired modes of action or, worse, false positive hits. In this set of best practices, we go over the essential steps of phenotypic drug discovery and provide guidance on how to increase the chance of success of identifying validated and relevant chemical starting points for optimization: selecting the right assay, selecting the right compound screening library and developing appropriate hit validation assays. Then, we highlight the importance of initiating studies to determine the mode of action of the identified hits early and present the current state-of-the-art.

Item Type:	Article
Date Deposited:	23 Nov 2021 00:45
Last Modified:	23 Nov 2021 00:45
URI:	https://oak.novartis.com/id/eprint/44210