Gallou, Fabrice (2021) Mild and robust Stille reactions in water using ppm levels of a new triphenylphosphine-based palladacycle. Angewandte Chemie. International edition, 60 (9). pp. 4158-4163.

Abstract

An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst leading to highly
effective Stille cross coupling reactions in water under mild conditions. Only 500-1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.

Item Type:	Article
Date Deposited:	15 Apr 2021 00:45
Last Modified:	15 Apr 2021 00:45
URI:	https://oak.novartis.com/id/eprint/43941