Freedman, Benjamin R, Kuttler, Andreas, Beckmann, Nicolau, Nam, Sungmin, Kent, Daniel, Farshad, Ramazani, Schuleit, Michael, Accart Gris, Nathalie, Rock, Anna, Li, Jianyu, Kurz, Markus, Fisch, Andreas, Ullrich, Thomas, Hast, Michael W, Tinguely, Yann , Weber, Eckhard and Mooney, David J (2022) Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity. Nature Biomedical Engineering.

Abstract

Hydrogels that provide mechanical support and sustainably release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with surrounding tissue. Here we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J m−2) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings. The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainably released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine
secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype. Hydrogels with ‘Janus’ surfaces and sustained-drug-release functionality could be designed for a range of biomedical applications.

Item Type:	Article
Date Deposited:	21 Jan 2022 00:45
Last Modified:	21 Jan 2022 00:45
URI:	https://oak.novartis.com/id/eprint/43583