Frederiksen, Mathias (2021) The kinase chemogenomic set (KCGS): An open science resource for kinase vulnerability identification. International Journal of Molecular Sciences, 22 (2). pp. 1-18. ISSN 14220067

Abstract

We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.

Item Type:	Article
Keywords:	Chemogenomic set Drug discovery Druggable genome KCGS Kinase inhibitor Phenotypic screening Protein kinase Small molecules Understudied kinase
Date Deposited:	25 May 2021 00:45
Last Modified:	25 May 2021 00:45
URI:	https://oak.novartis.com/id/eprint/43431