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A critical appraisal of structure-based drug design.

Tintelnot-Blomley, Marina and Lewis, Richard A (2006) A critical appraisal of structure-based drug design. IDrugs : the investigational drugs journal, 9 (2). pp. 114-118. ISSN 1369-7056


Even though conceptually started in the early 1980s, the use of protein structure information in drug discovery has never reached the current level of significance, nor has it experienced the revolutionary development that it is currently undergoing. Initially used for lead optimization, structure-based drug design (SBDD) now covers and supports virtually all steps in the drug- discovery pipeline. This commentary is a critical appraisal of the current state of the art, examining both successes and failures. Future directions in SBDD are also discussed.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); On a non-profit server
Keywords: Crystallography; drug design; high-throughput screening; protein flexibility; protein-ligand interaction
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Date Deposited: 14 Dec 2009 14:00
Last Modified: 14 Dec 2009 14:00


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