Leemans Martin, Laura, Peschke, Theo, Venturoni, Francesco and Mostarda, Serena (2020) Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis. Current Opinion in Green and Sustainable Chemistry, 25. ISSN 24522236

Abstract

In response to a growing demand for more sustainable and cost-effective synthetic processes, the pharmaceutical industry is increasingly relying on continuous manufacturing as a valuable alternative to conventional batch processing. Particularly, flow processing may enable process intensification of chemocatalytic and biocatalytic transformations, both being of strategic importance on the design and production of active pharmaceutical ingredients. This review outlines the current status of flow chemocatalysis and biocatalysis within the pharmaceutical landscape. Furthermore, the trends and challenges that these technologies face are highlighted, based on recently disclosed applications from industry and innovative solutions from academia.

Item Type:	Article
Keywords:	Pharmaceutical Industry; Continuous Manufacturing; Flow Chemistry; Chemocatalysis; Biocatalysis; Active Pharmaceutical Ingredients
Date Deposited:	01 Aug 2020 00:45
Last Modified:	01 Aug 2020 00:45
URI:	https://oak.novartis.com/id/eprint/42542