Blank, Jutta, Hintermann, Samuel, Schneider, Nadine, Schuffenhauer, Ansgar and Shultz, Michael (2020) Outline for a Perspective Article on Novartis’ approach to compound screening for hit and lead finding and the design of compounds sets for diversity driven screening. Journal of medicinal chemistry for publisher only.

Abstract

Description of the new NIBR compound screening deck and the underlying design principles. We plan to publish this as a perspective in JMC. It will include our solubility and permeability model, Methods of defining diversity, sub-structure filters and be examplified with structures from our collection, which are non-exclusive and already know in the public Domain (with PubChem numbers).
The actual article has not yet been written and will only be submitted to OAK once we are invited by JMC to submit a perspective.

Item Type:	Article
Keywords:	compound screening, hit finding, leading finding
Date Deposited:	12 May 2020 00:45
Last Modified:	12 May 2020 00:45
URI:	https://oak.novartis.com/id/eprint/42483