Mortzfeld, Frederik, Polenk, Jutta, Guelat, Bertrand, Venturoni, Francesco, Schenkel, Berthold and Filipponi, Paolo (2020) Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions. Organic Process Research & Development. ISSN 1083-61601520-586X

Abstract

A new method for the calorimetric characterization of high-energetic, fast reactions in flow mode has been developed. The use of an engineered flow reactor in combination with a process modelling software allowed the deconvolution of the reaction enthalpy from space-resolved temperature profiles. The new procedure was verified in a comparison with a conventional batch calorimeter and subsequently implemented for the thermal characterization of an organolithium flow process. The information collected for this reaction successfully supported a scale-up to the pilot plant. Overall, the new approach resulted to be superior when compared with established procedures, enabling the generation of precise calorimetric data in an accurate scale-down flow device.

Item Type:	Article
Date Deposited:	29 Jul 2020 00:45
Last Modified:	29 Jul 2020 00:45
URI:	https://oak.novartis.com/id/eprint/42351