Schirle, Markus (2020) Characterizing drug-target interactions in complex tissues. Trends in pharmacological sciences. ISSN 1873-3735

Abstract

Recently, Perrin et al. reported that the coupling of the cellular shift assay with an unbiased proteomics read-out (Thermal Proteome Profiling, TPP) can be applied to complex tissue samples from model organisms and patients. This study demonstrates that TPP enables organ-specific target engagement and identification studies even in patient-derived material.

Item Type:	Article
Date Deposited:	14 Apr 2020 00:45
Last Modified:	14 Apr 2020 00:45
URI:	https://oak.novartis.com/id/eprint/42347