Blanco, Maria-Jesus (2020) New Chemical Modalities and Strategic Thinking in Early Drug Discovery. ACS medicinal chemistry letters, 11 (3). pp. 228-231. ISSN 1948-5875

Abstract

Abstract: The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates and gene therapy have matured with clinical successes and are now considered early in target appraisal. In this viewpoint, we highlight recent progress in the field.

Item Type:	Article
Keywords:	Oligonucleotides, RNA, PROTAC, E3, ubiquitination, cyclopeptides, macrocycles, antibody-drug conjugates (ADC), gene therapy, chemical modalities, target validation, strategy
Date Deposited:	11 Apr 2020 00:45
Last Modified:	11 Apr 2020 00:45
URI:	https://oak.novartis.com/id/eprint/41691