Karle, Anette (2020) Applying MAPPs assays to assess immunogenicity. Frontiers in immunology, 11. ISSN 1664-3224

Abstract

Immunogenicity against biotherapeutic proteins (BPs) and the outcome for the patient are difficult to predict. In vitro assays that can help to assess the immunogenic potential of BPs are not yet used routinely during drug development. MAPPs (MHC associated peptide proteomics) is one of the assays best characterized regarding its value for immunogenicity potential assessment. This review is focusing on recent studies that have employed human HLA class II-MAPPs assays to rank biotherapeutic candidates, investigate clinical immunogenicity and understand mechanistic root causes of immunogenicity. Advantages and challenges of the technology are discussed as well as the different areas of application.

Item Type:	Article
Keywords:	MAPPs assay
Date Deposited:	28 Nov 2023 00:46
Last Modified:	28 Nov 2023 00:46
URI:	https://oak.novartis.com/id/eprint/41671