Chen, Hong (2006) Cellular inflammatory responses: novel insights for obesity and insulin resistance. Pharmacological research : the official journal of the Italian Pharmacological Society, 53 (6). pp. 469-477. ISSN 1043-6618

Abstract

Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary lifestyle are the main environmental causes for the development of insulin resistance and type 2 diabetes. In the past decade, it has been increasingly recognized that obesity and insulin resistance are associated with chronic, low-grade systemic inflammation. This review will cover the recent advances in this field and provide a working model explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.phrs.2006.03.003
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Insulin resistance; Obesity; Diabetes; Cellular inflammatory response; Chronic inflammation
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.phrs.2006.03.003
Date Deposited:	14 Dec 2009 14:00
Last Modified:	14 Dec 2009 14:00
URI:	https://oak.novartis.com/id/eprint/413