Osborne, Colin, Leitner, Ingrid, Hofbauer, Bettina, Fielding, Ceri A, Favre, Bertrand and Ryder, Neil (2006) Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy, 50 (6). pp. 2234-2236. ISSN 0066-4804

Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Item Type:	Article
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Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... http://www.pubmedcentral.nih.gov/article...
Date Deposited:	14 Dec 2009 14:00
Last Modified:	14 Dec 2009 14:00
URI:	https://oak.novartis.com/id/eprint/406