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Validating cancer drug targets.

Benson, John, Chen, Ying-Nan, Cornell-Kennon, Susan, Dorsch, Marion, Kim, Sunkyu, Leszczyniecka, Magdalena, Sellers, William and Lengauer, Christoph (2006) Validating cancer drug targets. Nature, 441 (7092). pp. 451-456. ISSN 1476-4687


A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is clinically effective and acts through the target against which it was designed. Nevertheless, it is desirable to declare an early-stage drug target as 'validated' before investing in a full-scale drug discovery programme dedicated to it. Although the outcome of validation studies can guide cancer research programmes, strictly defined universal validation criteria have not been established.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 14 Dec 2009 14:00
Last Modified: 31 Jan 2013 01:18


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