Schmitt, Esther, Roggo, Silvio, Miault, Charlotte, Krastel, Philipp, Noble, Christian, Beer, David, Rao, Srinivasa, Au, Melvin, Niyomrattanakit, Pornwaratt, Zheng, Jun, Jeffery, Douglas, Pethe, Kevin and Camacho, Luis (2011) The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease. Angewandte.

Abstract

Tuberculosis presents a major global health challenge. With the expansion of drug resistance and the spread of extremely-drug resistant Mycobacterium tuberculosis strains, the identification of novel drug targets has become paramount. Here we show that the ATP-dependent chaperone ClpC1 is the target of cyclomarin, a potent anti-mycobacterial natural product. Our findings validate the Clp protease as a novel drug target in Mtb in both growing and hypoxic non-growing bacteria.

Item Type:	Article
Date Deposited:	25 Apr 2016 23:45
Last Modified:	25 Apr 2016 23:45
URI:	https://oak.novartis.com/id/eprint/4022