Schuepp, Patrick (2019) Green Chemistry Benchmarking and improvement proposals for the CHAD Green Chemistry Scorecard Process. MS Thesis from UZH.

Abstract

The CHAD Green Chemistry process is the current method, which is applied by Novartis to visualize the envi-ronmental impact of a drug manufacturing process. This report describes the methodology behind the No-vartis method as well as for other advanced methodologies (e.g. Green Aspiration Level, Green Star, Eco Scale, methodology from Bristol-Meyers Squibb, methodology from F. Hoffmann-La Roche etc.).

The mentioned methods were applied on the real project from Novartis and compared with the results from the current method from Novartis. The other methods were often not distinctive enough or did not taken into account the complexity of the process. Therefore, no other method were available without further change. However, the other methods have shown different advantages.

The collected information from other methodologies were used to propose improvement suggestions. The most promising ideas (using individual values for each solvent, applying HSE criteria on solvent group and categorization of reagents according to their complexity and health concern) were applied on the real pro-jects and compared to the old processes.

All the improvement suggestion leaded to higher score. The impact for the reagents were lower than for the organic solvent, because in average were around four times less reagent used than organic solvents. The impacts of combining the different ideas for solvent results in a significant lower result ( for the project as well as leading to an increased distinction for the projects.

To further illustrate it, projects in different development phases were compared against each other (early phase against commercial) and it could be shown, that using a too simple approach (current Novartis ap-proach) can lead in certain cases to misleading goals.

Item Type:	Article
Date Deposited:	23 Jul 2019 00:45
Last Modified:	23 Jul 2019 00:45
URI:	https://oak.novartis.com/id/eprint/39921