Pan, Yue (2019) The dark side of fluorine. ACS Medicinal Chemistry Letters. pp. 1016-1019. ISSN 19485875

Abstract

Despite the perceived stability of the C-F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists' attention.

Item Type:	Article
Keywords:	CYP TDI defluorination Fluorine reactive metabolite
Date Deposited:	27 Aug 2019 00:45
Last Modified:	27 Aug 2019 00:45
URI:	https://oak.novartis.com/id/eprint/39439