Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor
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Martin, Laetitia, Marzinzik, Andreas, Ley, Steven V. and Baxendale, Ian R. (2010) Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow reactor. Organic Letters. ISSN 1523-7052
Official URL: http://pubs.acs.org/doi/abs/10.1021/ol1027927
Abstract
A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines
Item Type: | Article |
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Additional Information: | archiving not formally supported by this publisher |
Keywords: | diazoketone; quinoxaline; flow chemistry |
Date Deposited: | 13 Oct 2015 13:15 |
Last Modified: | 13 Oct 2015 13:15 |
URI: | https://oak.novartis.com/id/eprint/3936 |