The widespread regulation of microRNA biogenesis, function and decay.
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Krol, Jacek, Loedige, Inga and Filipowicz, Witold (2010) The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews. Genetics, 11 (9). pp. 597-610. ISSN 1471-0064
Abstract
MicroRNAs (miRNAs) are a large family of post-transcriptional regulators of gene expression that are approximately 21 nucleotides in length and control many developmental and cellular processes in eukaryotic organisms. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. More recently, it has become apparent that miRNA regulators themselves are subject to sophisticated control. Many reports over the past few years have reported the regulation of miRNA metabolism and function by a range of mechanisms involving numerous protein-protein and protein-RNA interactions. Such regulation has an important role in the context-specific functions of miRNAs.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 04 Dec 2010 00:45 |
| Last Modified: | 01 Feb 2013 00:48 |
| URI: | https://oak.novartis.com/id/eprint/3909 |