Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents.

Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes and Guagnano, Vito (2006) Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. Journal of Medicinal Chemistry, 49 (15). pp. 4451-4454. ISSN 0022-2623

Abstract

FLT3 kinase inhibitors are currently under investigation as a new treatment for acute myeloid leukemia. We report here a molecular concept invoking interactions between an aromatic ring and the side chains of Phe691 and Cys828, two residues of the ATP pocket, to obtain potent and specific inhibitors of this kinase. The hypothesis has been validated by the successful design of a new inhibitor prototype showing promising antiproliferative activity in cellular assays.

Item Type: Article
Related URLs:
Additional Information: archiving not formally supported by this publisher
Related URLs:
Date Deposited: 14 Dec 2009 14:00
Last Modified: 31 Jan 2013 01:18
URI: https://oak.novartis.com/id/eprint/390

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.