4-AMINOTHIAZOLYL ANALOGS OF GE2270 A: DESIGN, SYNTHESIS AND EVALUATION OF IMIDAZOLE ANALOGS
Tools
Tools
Lamarche, Matthew, Leeds, Jennifer, Mullin, Steve, Patane, Michael, Rann, Elin, Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-AMINOTHIAZOLYL ANALOGS OF GE2270 A: DESIGN, SYNTHESIS AND EVALUATION OF IMIDAZOLE ANALOGS. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3210-3215. ISSN 0960-894X
Abstract
Imidazole analogs of the antibiotic natural product GE2270 A (1) were designed, synthesized, and evaluated for Gram positive bacteria growth inhibition. A recently reported, copper-mediated synthesis was exploited to prepare the 4-thiazolyl imidazole analogs of GE2270 A. The synthesis described represents a structurally complex, natural product-based application of this recently reported synthetic methodology. In addition, the biological evaluation of the imidazole-based analogs further define the SAR of the 4-aminothiazolyl-based template.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | GE2270 A, Curtius, elongation factor Tu, antibiotic, imidazole, drug discovery |
| Related URLs: | |
| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/3896 |