Lamarche, Matthew, Leeds, Jennifer, Gunderson, Karl, Krastel, Philipp, Memmert, Klaus, Patane, Michael, Rann, Elin, Schmitt, Esther, Wang, Bing, Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding. Journal of medicinal chemistry, 54 (7). pp. 2517-2521. ISSN 0022-2623

Abstract

4-Aminothiazolyl analogs of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for G+ bacteria growth inhibition. The aminothiazole-based chemical template was evaluated for chemical stability and its decomposition revealed a novel, structurally simplified, des-thiazole analog of GE2270 A. Subsequent stabilization of the 4-aminothiazolyl functional motif was achieved and initial structure activity relationships defined.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Additional Information:	archiving not formally supported by this publisher
Keywords:	EFT, EF-Tu, elongation factor Tu, GE2270 A, aminothiazole, Curtius
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/3805