Gallou, Fabrice (2019) Sustainability challenges in peptide synthesis and purification: from R&D to production. The journal of organic chemistry : JOC, 84 (8). pp. 4615-4628.

Abstract

In recent years there has been a growing interest on therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs in the market, approximately 170 in clinical trials and >200 in preclinical development. However, the current state of the art in peptide synthesis involves primarily legacy technologies with usage of large amounts of highly hazardous reagents and solvents and little focus on green chemistry and engineering. In 2016 the ACS Pharmaceutical Roundtable identified the greener synthesis of peptides as a critical unmet need and a new Roundtable team formed to address this important area. The initial focus of this group is to highlight best practices in peptide synthesis and encourage much needed innovations. In this perspective, we aim to summarise the current challenges of peptide synthesis and purification in terms of sustainability, highlight possible solutions and encourage synergies between academia and industry and between the pharmaceutical industry and CROs/CMOs.

Item Type:	Article
Date Deposited:	11 Jun 2019 00:45
Last Modified:	11 Jun 2019 00:45
URI:	https://oak.novartis.com/id/eprint/37947