Li, Ning, Rice, Dennis, Grosskreutz, Cyndy, Prasanna, Ganesh, Dryja, Thaddeus, Wang, Shirley and Gagne, Joshua (2019) Using healthcare databases to explore associations between drugs and progression of open angle glaucoma. Clinical pharmacology and therapeutics. ISSN 1532-6535

Abstract

We sought to refine understanding about associations identified in prior studies between angiotensin-II receptor blockers, metformin, selective serotonin reuptake inhibitors, fibric-acid derivatives, or calcium channel blockers and progression to glaucoma filtration surgery for open-angle glaucoma (OAG). We used new-initiator, active-comparator cohort designs to investigate these drugs in two data sources. We adjusted for confounders using stabilized inverse-probability-of-treatment weights and evaluated results using "intention-to-treat" and "as-treated" follow-up approaches. In both data sources, Kaplan-Meier curves showed trends for more rapid progression to glaucoma filtration surgery in patients taking calcium channel blockers compared with thiazides with as-treated (MarketScan P = 0.15; Medicare P = 0.03) and intention-to-treat follow-up (MarketScan P < 0.01; Medicare P = 0.10). There was suggestion of delayed progression for selective serotonin reuptake inhibitor compared with tricyclic antidepressants in Medicare, which was not observed in MarketScan. Our study provided support for a relationship between calcium channel blockers and OAG progression but not for other investigated drugs.

Item Type:	Article
Date Deposited:	13 Aug 2019 00:45
Last Modified:	13 Aug 2019 00:45
URI:	https://oak.novartis.com/id/eprint/37425