Gallou, Fabrice (2018) Copper-Catalyzed Oxidative Cleavage of Electron-Rich Olefins in Wa-ter at Room Temperature. Organic letters, 20 (17). pp. 5094-5097.

Abstract

A copper-catalyzed oxidative cleavage of electron-rich olefins into their corresponding carbonyl derivatives is described as an alternative to ozonolysis. The scope includes various precursors to aryl ketone derivatives, as well as oxida-tions of enol ethers bearing atypical alkyl and dialkyl substitution, the first of their kind among such metal catalyzed alkene cleavage reactions. The use of an inexpensive copper salt, room temperature conditions, an aerobic atmosphere, and water as the global reaction medium highlight the green features of this new method. Associated mechanistic investigations are also presented.

Item Type:	Article
Date Deposited:	13 Nov 2018 00:45
Last Modified:	13 Nov 2018 00:45
URI:	https://oak.novartis.com/id/eprint/36886