Teno, Naoki, Miyake, Takahiro, Ehara, Takeru, Irie, Osamu, Sakaki, Junichi, Ohmori, Osamu, Gunji, Hiroki, Matsuura, Naoko, Masuya, Keiichi, Hitomi, Yuko, Nonomura, Kazuhiko, Horiuchi, Miyuki, Gohda, Keigo, Iwasaki, Atsuko, Umemura, Ichiro, Tada, Sachiyo, Kometani, Motohiko, Iwasaki, Genji, Cowan-Jacob, Sandra, Missbach, Martin, Lattmann, Rene and Betschart, Claudia (2007) Novel scaffold for cathepsin K inhibitors. Bioorganic & Medicinal Chemistry Letters, 17 (22). pp. 6096-6100. ISSN 0960-894X

Abstract

Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Cathepsin K inhibitors; Pyrrolopyrimidine; Novel scaffold
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	14 Dec 2009 14:01
Last Modified:	31 Jan 2013 01:18
URI:	https://oak.novartis.com/id/eprint/360