Gallou, Fabrice (2016) EvanPhos. A New Ligand for ppm Level Pd-Catalyzed Suzuki-Miyaura Couplings in Either Organic Solvent or Water. Ang Chem Int Ed, 55 (16). pp. 4914-4918.

Abstract

In only two chemical steps, a new biaryl platform can be constructed that complexes Pd(OAc)2 forming a precursor to a very active catalyst useful for Suzuki-Miyaura cross-couplings. By a combination of catalyst pre-activation, used together with the uncommon solvent EtOAc, this catalyst system is effective at loadings in the ppm (0.1-0.5 mol %) range with highly functionalized reaction partners. Similar reactions run in water containing nanomicelles are as fast or faster. The
stability of this new ligand, EvanPhos, as its derived Pd catalyst, is also shown to have considerable stability at rt

Item Type:	Article
Date Deposited:	29 May 2018 00:45
Last Modified:	29 May 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35784