Lima, Fabio, Grunenberg, Lars, Husaini, Mohamed, Labes, Ricardo, Sedelmeier, Joerg Mathias and Ley, Steven (2018) Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow. Chemical Communications, 54 (44). pp. 5606-5609. ISSN 1364548X

Abstract

We report an acridium-based organic photocatalyst as an efficient replacement for iridium-based photocatalysts to oxidise boronic acid derivatives by a single electron process. Furthermore, we applied the developed catalytic system to the synthesis of four active pharmaceutical ingredients (APIs). A straightforward scale up approach using continuous flow photoreactors is also reported affording gram an hour throughput.

Item Type:	Article
Date Deposited:	17 Jul 2018 00:45
Last Modified:	17 Jul 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35684