Application of mass spectrometry technologies for the discovery of low-molecular weight modulators of enzymes and protein-protein interactions.
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Zehender, Hartmut and Mayr, Lorenz (2007) Application of mass spectrometry technologies for the discovery of low-molecular weight modulators of enzymes and protein-protein interactions. Current Opinion in Chemical Biology, 11 (5). pp. 511-517. ISSN 1367-5931
Abstract
In recent years, mass spectrometry has gained widespread use as an assay and screening technology in drug discovery because it enables sensitive, label-free detection of low-molecular weight modulators of biomolecules as well as sensitive and accurate detection of high-molecular weight modifications of biomolecules. Electrospray and matrix-assisted laser desorption ionization are the most widely used ionization techniques to identify chemical compounds interfering with enzymatic function, receptor-ligand binding or molecules modulating a protein-protein interaction of interest. Mass spectrometry based techniques are no longer restricted to screening in biochemical assay systems but have now become also applicable to imaging of biomolecules and chemical compounds in cell-based assay systems and even in highly complex tissue sections.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
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| Date Deposited: | 14 Dec 2009 14:01 |
| Last Modified: | 31 Jan 2013 01:18 |
| URI: | https://oak.novartis.com/id/eprint/356 |