Lapp, Stefanie, Bube, Axel, Ernst, Heinrich, Colbatzky, Florian, Kellner, Rupert, Nolte , Thomas and Rinke, Matthias (2018) Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*). Best Practice Approach for Assessment of Microchip-Associated Tumors in Non-Clinical Safety Studies: Position of the Registry of Industrial Toxicology Animal-data (RITA*).

Abstract

Microchip implantation is a common and widely employed means of animal identification in laboratory animal facilities. However, these devices have been associated with tumors of the skin and subcutis in rodents. While microchip-associated tumors are rare, they pose a challenge for accurate diagnosis and documentation in pre-clinical toxicity studies. Documentation of these tumors should differentiate microchip-associated lesions with spontaneously occurring or substance-induced tumors. Standardizing criteria for microchip-associated lesions will aid the diagnostic process and allow for pre-clinical regulatory standardization. To this end, the Registry of Industrial Toxicology Animal-data (RITA) has developed clear recommendations for diagnosis and documentation of microchip-associated lesions.

Item Type:	Article
Keywords:	INHAND; RITA; best practice recommendations; implantation; microchip-associated tumors; recording; sampling; soft tissue tumors
Date Deposited:	27 Nov 2018 00:45
Last Modified:	27 Nov 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35160