Gallou, Fabrice and Handa, Sachin (2017) Micelle-Enabled Sustainable Heteroleptic Palladium Catalysis for Nitroalkane Arylations in Water Under Mild Conditions. ACS Catalysis.

Abstract

This work demonstrates a significant advance in the area of palladium catalysis and cross-coupling chemistry in particular. Specifically, it offers the synthetic community a palladium catalyzed arylation of nitroalkanes that is noteworthy for: (1) low palladium loading; (2) generally applicablity to a broad range of functionalities; (3) very mild conditions; and (4) use of an aqueous reaction medium that avoids organic solvents, requires very little water, and allows for “in-flask” recycling of the surfactant, water, and catalyst.

Item Type:	Article
Date Deposited:	24 Oct 2017 00:45
Last Modified:	24 Oct 2017 00:45
URI:	https://oak.novartis.com/id/eprint/33861