Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning.

Bissiere, Stephanie and Plachta, Nicolas and Hoyer, Daniel and Mcallister, Kevin and Olpe, Hans-Rudolf and Grace, Anthony and Cryan, John F. (2008) The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning. Biological Psychiatry, 63 (9). pp. 821-831. ISSN 1873-2402

Abstract

BACKGROUND: The rostral anterior cingulate cortex (rACC) and the amygdala consistently emerge from neuroimaging studies as brain regions crucially involved in normal and abnormal fear processing. To date, however, the role of the rACC specifically during the acquisition of auditory fear conditioning still remains unknown. The aim of this study is to investigate a possible top-down control of a specific rACC sub-region over amygdala activation during pavlovian fear acquisition. METHODS: We performed excitotoxic lesions, temporal inactivation, and activation of a specific sub-region of the rACC that we identified by tracing studies as supporting most of the connectivity with the basolateral amygdala (r(Amy)-ACC). The effects of these manipulations over amygdala function were investigated with a classical tone-shock associative fear conditioning paradigm in the rat. RESULTS: Excitotoxic lesions and transient inactivation of the r(Amy)-ACC pre-training selectively produced deficits in the acquisition of the tone-shock associative learning (but not context). This effect was specific for the acquisition phase. However, the deficit was found to be transient and could be overcome by overtraining. Conversely, pre-training transient activation of the r(Amy)-ACC facilitated associative learning and increased fear expression. CONCLUSIONS: Our results suggest that a subregion of the rACC is key to gating the efficiency of amygdala-dependent auditory fear conditioning learning. Because r(Amy)-ACC inputs were confirmed to be glutamatergic, we propose that recruitment of this brain area might modulate overall basolateral amygdala excitatory tone during conditioned stimulus-unconditioned stimulus concomitant processing. In the light of clinical research, our results provide new insight on the effect of inappropriate rACC recruitment during emotional events.

Item Type: Article
Related URLs:
Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Amygdala, anterior cingulate cortex, fear acquisition, fear conditioning, medial prefrontal modulation
Related URLs:
Date Deposited: 14 Dec 2009 14:01
Last Modified: 14 Dec 2009 14:01
URI: https://oak.novartis.com/id/eprint/336

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.