Cellular studies of MrDb (DDX18).
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Dubaele, Sandy and Chene, Patrick (2007) Cellular studies of MrDb (DDX18). Oncology Research, 16 (12). pp. 549-556. ISSN 0965-0407
Abstract
Helicases are present in viruses, prokaryotes, and eukaryotes, and several of them have been linked to human diseases. Here we study the role of one putative DEAD-box RNA helicase, MrDb (DDX18), in tumor cells. We show that MrDb is a nucleolar protein ubiquitously expressed in tumor cells and that it is more abundantly expressed in proliferating cells. Inhibition of MrDb with dominant negative mutant or a shRNA reduces tumor cell proliferation without inducing a cell cycle arrest or apoptosis. These findings suggest that MrDb is important for cell proliferation and that its inhibition could prevent tumor cell proliferation.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | RNA HELICASES; MYC; GENE; TARGET; CELLS; TRANSCRIPTION; INHIBITION; MECHANISM |
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| Date Deposited: | 14 Dec 2009 14:01 |
| Last Modified: | 31 Jan 2013 01:19 |
| URI: | https://oak.novartis.com/id/eprint/334 |