Parmentier, Michael, Guo, Murphy, Zhou, Jianguang, Gallou, Fabrice, Gabriel, Christopher and Isley, Nicholas (2017) Switching from organic solvents to water at an industrial scale. Current Opinion in Green and Sustainable Chemistry, 7. pp. 13-17. ISSN 24522236

Abstract

The paper presents the most recent advances in applications of alternative medium to replace polar aprotic solvent such as Dimethylformamide (DMF), Dimethylacetamide (DMAc) or N-Methyl-2-pyrrolidone (NMP). Focus is made on the use of nonionic designer surfactant (e.g. TPGS-750-M) in water instead of traditional organic solvents. Much attention is given to its application on most commonly used transformations in active pharmaceutical ingredient (API) synthesis such as amidation reaction, Suzuki-Miyaura cross-coupling and nitro group reduction. Case studies of successful process development to attain improved green processes are included. Future directions and most recent results using tailor-made reagents suitable for micellar environment are given.

Item Type:	Article
Date Deposited:	22 Apr 2020 00:45
Last Modified:	22 Apr 2020 00:45
URI:	https://oak.novartis.com/id/eprint/32770