Silver-Brown, Serena, Hoffman, Ann, Horvath, Peter, Lovitt, Carrie, Easton, Evan, LaBarbera, Daniel, Mendez, Melissa, Rothernberg, Mark, Seldin, Jan and Fennell, Myles (2017) SBI2 HCS/HCA 3D Imaging: Best Practices and Unmet Needs Colloquium. Assay and drug development technologies, 15 (1). pp. 1-7.

Abstract

In this, the third annual SBI2 conference, the afternoon of the opening day was dedicated to short presentations and discussions revolving around HCS/HCA 3D Imaging: Best Practices and Unmet Needs. The growing interest in conducting assays in 3D is driven by the realization that there is often a disconnect between observations made with cells grown in 2D in a tissue culture plate and biology occurring in an organism which occurs in context of other cell types and a complex extracellular matrix. This is apparent when you look at the high failure rate of early candidates in the drug discovery process. The push towards 3D assay systems is an attempt to increase clinical relevance, while at the same time preserving an acceptable level of throughput to evaluate potential clinical candidates. With growing scientific interest in 3D biology imaging-based assays are emerging as an obvious choice to measure complex phenotypes and move towards the realization and quantification of the concept of an “organ in a dish”.

Item Type:	Article
Date Deposited:	11 Feb 2017 00:45
Last Modified:	11 Feb 2017 00:45
URI:	https://oak.novartis.com/id/eprint/31650