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Pharmacological blockade of the chemokine receptor CCR1 protects mice from systemic candidiasis of hematogenous o

Lionakis, Michail S. and Albert, Nathaniel D. and Swamydas, Muthulekha and Lee, Richard C. C. and Loetscher, Pius and Kontoyiannis, Dimitrios P. (2016) Pharmacological blockade of the chemokine receptor CCR1 protects mice from systemic candidiasis of hematogenous o. Antimicrobial agents and chemotherapy.

Abstract

Systemic candidiasis is a leading cause of nosocomial bloodstream infection with high mortality despite treatment. Immune-based strategies are needed to improve outcomes. We previously reported that genetic deficiency in the chemokine receptor CCR1 improves survival and ameliorates immunopathology in Candida-infected mice. Herein, we found that treatment of immunocompetent Candida-infected mice with the CCR1-selective antagonist BL5923 improves survival, decreases kidney fungal burden and protects from renal tissue injury, showing promise as a potential immune-based therapeutic intervention.

Item Type: Article
Date Deposited: 21 Dec 2016 00:45
Last Modified: 21 Dec 2016 00:45
URI: https://oak.novartis.com/id/eprint/31504

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