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The Northeast Regional SPS Meeting Update: Safety Pharmacology Innovations and Applications

Pannirselvam, Malar , Brabham, Tiffini, Botchway, Alfred W. , Hodges, Donald B. , Traebert, Martin and Pugsley, Michael K. (2016) The Northeast Regional SPS Meeting Update: Safety Pharmacology Innovations and Applications. Journal of pharmacological and toxicological methods, 16. pp. 30152-30156. ISSN 10568719


The Safety Pharmacology Society (SPS) held a Northeast (NE) regional meeting in Boston, MA on May 13, 2016 at the Vertex Pharmaceuticals site. There were 103 attendees from the pharmaceutical industry, contract research organizations (CROs), academia, and global regulatory agencies. An assortment of scientific topics were presented by 7 speakers that included broad topics in the cardiovascular (organ on chip, statistical power and translation of rat cardiovascular telemetry data and dual inhibition of IKr and IKs on QT interval prolongation) and central nervous system (in vitro platform for neurotoxicity, an integrated risk assessment of suicidal ideation and behavior, and EEG advances in safety pharmacology) as well and a novel topic discussing preclinical challenges faced in the development of a novel gene therapy. A highlight of the meeting was an in-depth discussion on the fatty acid acyl hydrolase (FAAH) inhibitor BIA 10-2474 which involved a presentation from the Biotrial (Rennes, France) team conducting the clinical trial followed by a comprehensive overview of the biology of FAAH. An additional poster session was held that included 14 fascinating posters on cutting edge safety pharmacology topics.

Item Type: Article
Date Deposited: 31 May 2017 00:45
Last Modified: 31 May 2017 00:45


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