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Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development.

Vicini, P and Fields, O and Lai, E and Litwack, E D and Martin, A-M and Morgan, T M and Pacanowski, M A and Papaluca, M and Perez, O D and Ringel, M S and Robson, M and Sakul, H and Vockley, J and Zaks, T and Dolsten, M and Søgaard, M (2016) Precision medicine in the age of big data: The present and future role of large-scale unbiased sequencing in drug discovery and development. Clinical pharmacology and therapeutics, 99 (2). pp. 198-207. ISSN 1532-6535

Abstract

High throughput molecular and functional profiling of patients is a key driver of precision medicine. DNA and RNA characterization has been enabled at unprecedented cost and scale through rapid, disruptive progress in sequencing technology, but challenges persist in data management and interpretation. We analyze the state-of-the-art of large-scale unbiased sequencing in drug discovery and development, including technology, application, ethical, regulatory, policy and commercial considerations, and discuss issues of LUS implementation in clinical and regulatory practice.

Item Type: Article
Date Deposited: 04 Oct 2016 00:45
Last Modified: 04 Oct 2016 00:45
URI: https://oak.novartis.com/id/eprint/31106

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