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New approaches to investigate drug-induced hypersensitivity

Ogese, Monday O. and Ahmed, Shaheda and Alferivic, Ana and Betts, Catherine J. and Dickinson, Anne and Faulkner, Lee and French, Neil and Gibson, Andrew and Hirschfield, Gideon M. and Kammueller, Michael and Meng, Xiaoli and Martin, Stefan F. and Musette, Philippe and Norris, Alan and Pirmohamed, Munir and Park, B. Kevin and Purcell, Anthony W. and Spraggs, Colin F. and Whritenour, Jessica and Naisbitt, Dean J. (2016) New approaches to investigate drug-induced hypersensitivity. Chemical Research in Toxicology, 30. ISSN 0893-228X1520-5010

Abstract

The workshop on “New approaches to investigate drug-induced hypersensitivity” was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts’ views on the different topics covered during the meeting.

Item Type: Article
Date Deposited: 07 Jan 2017 00:45
Last Modified: 07 Jan 2017 00:45
URI: https://oak.novartis.com/id/eprint/30990

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