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Flash Chemistry on Multigram-Scale: Continuous Flow Synthesis of Boronic Acids within a Second

Hafner, Andreas and Meisenbach, Mark and Sedelmeier, Joerg Mathias (2016) Flash Chemistry on Multigram-Scale: Continuous Flow Synthesis of Boronic Acids within a Second. Organic Letters. ISSN 1523-70601523-7052

Abstract

The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on multigram-scale is described. The developed metalation platform allows for the performance of organolithium chemistry on mulitgram scale mimicking the concept of flash chemistry. This setup embodies a valuable complement to existing methodologies as it combines the benefits of Flash Chemistry (chemical synthesis on a timescale of <1 s) with remarkable throughput while mitigating the risk of blockages.

Item Type: Article
Date Deposited: 16 Jul 2016 00:45
Last Modified: 16 Jul 2016 00:45
URI: https://oak.novartis.com/id/eprint/29818

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