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Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization

Tian, Hua and Wucher, Andrea and Winograd, Nicholas (2016) Reducing the matrix effect in organic cluster SIMS using dynamic reactive ionization. Journal of the American Society for Mass Spectrometry, 27 (2). pp. 2014-2024. ISSN 1879-1123

Abstract

Dynamic reactive ionization (DRI) utilizes the reactive molecule, HCl, which is fused into Ar cluster projectile and activated at the bombardment site on the sample surface with the presence of water. The methodology has been proved to enhance the ionization of protonated molecular ion and reduce the salt effect in the complex biomatrix. In the study, the methodology is applied to depth profile the irganox 1098/1010 multilayer system, which has shown the strong matrix effect, consequently, the quantitative depth profiling is impossible using secondary ion mass spectrometry (SIMS). The systematic comparisons show the 4~10 folds of enhancement of protonated ions for both components in compare with using pure Ar cluster, resulting in a uniform depth profiling in positive mode, and almost no matrix effect in negative mode. The methodology offers a new opportunity to tackle the matrix effect and might lead to a quantitative analysis using SIMS.

Item Type: Article
Date Deposited: 09 Nov 2016 00:45
Last Modified: 09 Nov 2016 00:45
URI: https://oak.novartis.com/id/eprint/29469

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