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DNA-encoded Chemistry: Enabling the deeper sampling of chemical space

Goodnow, Robert A. and Dumelin, Christoph and Keefe, Anthony D. (2016) DNA-encoded Chemistry: Enabling the deeper sampling of chemical space. Nature Reviews Drug Discovery. ISSN 1474-17761474-1784

Abstract

DNA–encoded chemical library technologies are increasingly being adopted by hit and lead generation scientists. DNA-encoded chemistry enables the exploration of chemical spaces four to five orders of magnitude more deeply than is achievable by high throughput screening methods. New opportunities and challenges that this technology has introduced include aqueous synthetic chemistry, building block diversity, oligonucleotide conjugation, large-scale molecular biological transformations, process design, selection methodologies, chemistry and DNA sequence informatics, and the analysis of large chemistry spaces. This review provides an overview of the development and application of DNA-encoded chemistry and also highlights the future directions of this potentially disruptive technology.

Item Type: Article
Date Deposited: 04 Jan 2017 00:45
Last Modified: 04 Jan 2017 00:45
URI: https://oak.novartis.com/id/eprint/29102

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