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Synthetic Phospholipids as Specific Substrates for Plasma Endothelial Lipase

Papillon, Julien and Pan, Meihui and Brousseau, Margaret and Gilchrist, Mark and Singh, Alok and Stawicki, Todd and Lou, Changgang and Thompson, Jed (2016) Synthetic Phospholipids as Specific Substrates for Plasma Endothelial Lipase. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3514-3517. ISSN 0960894X

Abstract

We designed and prepared synthetic phospholipids that generate lyso-PC products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100 emulsion or incorporated in synthetic HDL particles can serve as a substrate for plasma EL with useful specificity.

Item Type: Article
Date Deposited: 12 Aug 2016 00:45
Last Modified: 12 Aug 2016 00:45
URI: https://oak.novartis.com/id/eprint/29015

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