Papillon, Julien, Pan, Meihui, Brousseau, Margaret, Gilchrist, Mark, Singh, Alok, Stawicki, Todd, Lou, Changgang and Thompson, Jed (2016) Synthetic Phospholipids as Specific Substrates for Plasma Endothelial Lipase. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3514-3517. ISSN 0960894X

Abstract

We designed and prepared synthetic phospholipids that generate lyso-PC products with a unique mass for convenient detection by LC-MS in complex biological matrices. We demonstrated that compound 4, formulated either as a Triton X-100 emulsion or incorporated in synthetic HDL particles can serve as a substrate for plasma EL with useful specificity.

Item Type:	Article
Date Deposited:	12 Aug 2016 00:45
Last Modified:	12 Aug 2016 00:45
URI:	https://oak.novartis.com/id/eprint/29015