Ullman, Brett R, Aja, Teresa, Chen, Ning, Diaz, Jose-Luis, Gu, Xin, Herrmann, Julia, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph J, Linton, Steven D, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Roggo, Silvio, Sayers, Robert O, Schmitz, Albert, Ternansky, Robert J, Tomaselli, Kevin J and Wu, Joe C (2005) Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads. Bioorganic & Medicinal Chemistry Letters, 15 (15). pp. 3632-3636. ISSN 0960-894X

Abstract

Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
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Date Deposited:	29 Apr 2010 23:45
Last Modified:	01 Feb 2013 00:49
URI:	https://oak.novartis.com/id/eprint/2859