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Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine

Bouchez, Laure and Gerbeaux, Cyril and rusch, marion and Livendahl, madeleine and Patoor, Maude and Press, Neil (2016) Wake Up Call of A Sleeping Beauty”: Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine. Synlett.

Abstract

We report a one-step process for the preparation of substituted b-(2-pyridyl)-ketones with a variety of functional groups. b-(2-Pyridyl)-ketones are a unique class of heterocycle with valuable physicochemical properties and emerging pharmacophores. More specifically we exemplified the importance of this building block in a short series of anti-malarial natural products.

Item Type: Article
Date Deposited: 17 Feb 2017 00:45
Last Modified: 17 Feb 2017 00:45
URI: https://oak.novartis.com/id/eprint/28558

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