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In vitro Antiviral Activity of Adenosine Analog NITD008 against Tick-borne Flaviviruses

Lo, Michael K. and Shi, Pei-Yong and Chen, Yen Liang and Flint, Mike and Spiropoulou, Christina F. (2016) In vitro Antiviral Activity of Adenosine Analog NITD008 against Tick-borne Flaviviruses. Antiviral Research, 130 (June 2). pp. 46-49. ISSN 1872-9096

Abstract

There are currently no antiviral therapies available for the tick-borne flaviviruses associated with
hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma
hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility to identify nucleoside analog inhibitors that have pan-flavivirus activity

Item Type: Article
Keywords: NITD008, Antiviral, Nucleoside analog, Tick-borne
Date Deposited: 12 Aug 2016 00:45
Last Modified: 12 Aug 2016 00:45
URI: https://oak.novartis.com/id/eprint/28545

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