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Reproducibility of Quantitative Indices of Lung Function and Microstructure from 129Xe Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy

Stewart, Neil J and Horn, Felix C and Norquay, Graham and Collier, Guilhem J and Yates, Denise and Lawson, Rod and Marshall, Helen and Wild, Jim M (2016) Reproducibility of Quantitative Indices of Lung Function and Microstructure from 129Xe Chemical Shift Saturation Recovery (CSSR) MR Spectroscopy. Magnetic Resonance in Medicine, 000 (000). pp. 1-7. ISSN 10.1002/mrm.26310

Abstract

Purpose: To evaluate the reproducibility of indices of lung microstructure and function derived from 129Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD). To study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level.
Methods: Preliminary data was collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, nine age-matched volunteers were scanned three times on one day, and five COPD patients were scanned on three separate days to assess short and long-term reproducibility.
Results: CSSR-derived alveolar septal thickness (ST) and surface-area-to-volume (S/V) ratio values decreased with lung inflation level (P<0.001; P=0.057, respectively). Intra-subject standard deviations of ST were lower than previously-measured differences between volunteers and subjects with interstitial lung disease. Coefficient of variation (CV) values of ST were 4.3±1.9% and 6.0±4.3% in volunteers and COPD patients, respectively, which are comparable to CV values for whole-lung diffusing capacity. The mean CV of S/V in volunteers and patients was 14.1±8.1% and 17.8±19.5%, respectively.
Conclusion: 129Xe CSSR presents a reproducible method for estimation of alveolar septal thickness.

Item Type: Article
Keywords: Magnetic Resonance Imaging, Hyperpolarized Xenon Lung Imaging, Chronic Obstructive Pulmonary Disease, pulmonary gas exchange
Date Deposited: 13 Aug 2016 00:45
Last Modified: 13 Aug 2016 00:45
URI: https://oak.novartis.com/id/eprint/28427

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