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Discovery of A Selective and Potent Inhibitor of MNK Kinase 1/2 Utilizing Structure-Based Drug Design

Han, Wooseok and Ding , Yu and Xu, Yongjin and Pfister, Keith and Zhu, Shejin and Warne, Robert and Doyle, Mike and Aikawa, Mina and Amiri, Payman and Appleton, Brent and Stuart, Darrin and Fanidi, Abdallah and Shafer, Cynthia (2016) Discovery of A Selective and Potent Inhibitor of MNK Kinase 1/2 Utilizing Structure-Based Drug Design. Journal of Medicinal Chemistry, 59 (7). pp. 3034-3045. ISSN 0022-26231520-4804

Abstract

The discovery of a highly potent and selective small molecule inhibitor 8 for in vitro target validation of MNK1/2 kinases is described. The aminopyrazine benzimidazole series was derived from an HTS hit and optimized by utilization of a docking model, conformation analysis, and binding pocket comparison against anti-targets.

Item Type: Article
Date Deposited: 27 Apr 2016 23:45
Last Modified: 27 Apr 2016 23:45
URI: https://oak.novartis.com/id/eprint/28344

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