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The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease

Van Eldik, LJ and Carrillo, M and Cole, PE and Feuerbach, Dominik and Greenberg, BD and Hendrix, J and Kennedy, M and Kozauer, N and Mueller, R and Ransohoff, R and Wilcock, DM and Bain, L and Bales, K (2016) The Roles of Inflammation and Immune Mechanisms in Alzheimer's Disease. Alzheimers Dementia, 2 (2). pp. 99-100. ISSN http://dx.doi.org/10.1016/j.trci.2016.05.001

Abstract

The Alzheimer's Association’s Research Roundtable met in April 2015 to explore the role of immune and inflammatory mechanisms in the progression of Alzheimer’s disease (AD). The ability of innate immune cells, such as microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a contributor to disease pathogenesis. Adaptive immunity also plays a role in responding to disease or injury in the central nervous system (CNS), while innate immunity appears to drive neuroinflammation. An increased understanding of these processes may lead to new therapeutic targets, animal models and biomarkers for AD. The barriers and challenges toward new treatments will be discussed.

Item Type: Article
Date Deposited: 13 Oct 2016 00:45
Last Modified: 13 Oct 2016 00:45
URI: https://oak.novartis.com/id/eprint/28011

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